files for
16 Apr 2008
Indiana researchers hope that examining the structure of huntingtin interacting proteins will uncover new information about HD.
10 Apr 2008
New research with the HD mice shows that starting exercise early helps delay the onset of motor symptoms.
28 Mar 2008
In a fruitfly model, the HD protein causes early synaptic problems which can be addressed through the genes which regulate calcium channels.
24 Mar 2008
UK researchers have found promising drugs which induce autophagy, an alternate way to clear away the HD protein.
12 Mar 2008
NCCAM and the Orphan Product Division of the FDA is funding a phase III clinical trial of medicinal grade creatine.
24 Feb 2008
Progress continues with CHDI's strategic efforts to develop treatments for Huntington's Disease.
12 Feb 2008
The FDA has information for your doctor about botox.
27 Jan 2008
The anesthesia isoflurane (brand name Forane) should not be administered to HD patients.
11 Jan 2008
Brightly colored fruits and vegetables rich in polyphenols help counter the negative effects of high fat food.
11 Jan 2008
Psychologists report on why we do not exercise when we know we should and how we can get motivated.
5 Jan 2008
Sertaline (Zoloft) improves symptoms, reduces brain atrophy, and prolongs survival in the R6/2 mice.
1 Jan 2008
The Predict-HD study has identified early, subtle, measurable changes that take place 10-20 years before diagnosis.
1 Jan 2008
High throughput screening has identified a compound which inhibits protein aggregation. Part 1 of 3.
1 Jan 2008
C2-8 moves another step on the research pipeline with success in a fruitfly model of HD. Part 2 of 3.
1 Jan 2008
R6/2 mice given C2-8 experience delayed progression of motor symptoms and reduced cell death. Part 3 of 3
29 Dec 2007
29 Dec 2007
A loss of BDNF in adult mice leads to overeating and obesity.
4 Dec 2007
Following promising results in mouse models, researchers at Buck Institute and NTI will work on developing FGF-2 as a drug for HD patients.
19 Nov 2007
One more Phase III clinical trial is needed to support a New Drug Application.
9 Nov 2007
New research into aging suggests that walnuts as well as the HDL favorite blueberries are good bets for a proactive diet.
8 Nov 2007
A Phase III clinical trial of 400 mg per day of minocycline accelerated disease progression in ALS patients.
26 Oct 2007
RNA interference using a different technology and a different mouse model achieves good results.
22 Oct 2007
Eight young adults who had undergone predictive testing were interviewed.
7 Oct 2007
Normal mice exposed to music have an increase in BDNF in the hippocampus.
7 Oct 2007
Researchers restored the capacity to retain new memories in fragile X syndrome mice by infusing BDNF to the hippocampus region.
7 Oct 2007
A synthetic version of an antioxidant with neuroprotect properties will be tested in animal models of HD.
5 Oct 2007
Young people who coped well were those with the most support, good relationships with others, and an early knowledge of HD
2 Oct 2007
Synthetic small interfering RNAs were safe and efficient in a rodent study.
1 Oct 2007
Neurosearch applies for permission to start Phase III clinical trials of ACR16, a dopamine stabilizer, in Europe and the U.S.
30 Sep 2007
Last call for participants in an At Risk study.
27 Sep 2007
CHDI and ActiveSight will work together to reduce the time it takes to develop new drugs to treat HD.
26 Sep 2007
23 Sep 2007
In a landmark study, researchers administered BDNF and noggin and induced neurogenesis and prolonged life in the R6/2 mice.
23 Sep 2007
This article describes other possible diagnoses when there are clinical signs of HD but a negative gene test.
16 Sep 2007
Alzheimer's patients who follow the Mediterranean diet live longer.
25 Aug 2007
The HD protein causes a depletion in cellular energy but not through direct effects on the mitochondria, the cell's energy factory.
24 Aug 2007
Exciting research suggests that restoring the expression of the genes that the HD protein suppresses could be a major treatment.
20 Aug 2007
The molecular zip code research suggests that a kinase inhibitor could be a major treatment for Huntington
19 Aug 2007
A Phase III clinical trial of the glutamate blocker riluzole failed to slow progression or improve symptoms in HD patients.
15 Aug 2007
A new study based on Venezuela data examines factors that might be associated with CAG instability.
12 Aug 2007
A new study of 29 JHD patients adds to our knowledge.
11 Aug 2007
Researchers analyzed a popular HD BB and concluded that HD family members exchange information and support.
1 Aug 2007
MRSSI, Inc. announced today that Daniel P. van Kammen MD, PhD has joined as Chief Medical Officer.
31 Jul 2007
John Hopkins University and the National Human Genome Research Institute are starting a new study for those at risk.
30 Jul 2007
The FDA shuts down a gene therapy trial for arthritis after a patient died.
28 Jul 2007
HSG announces a Phase II study of Dimebon
21 Jul 2007
Massachusetts General Hospital researchers have developed a new drug for protein misfolding diseases.
6 Jul 2007
CAG counts are not related to the probability of developing a psychiatric disorder nor the severity of psychiatric symptoms in HD gene carriers.
28 Jun 2007
Lowered BDNF levels in HD patients can be measured through blood tests and could serve as a biomarker.
26 Jun 2007
HD specific human cell systems to be developed to improve drug discovery.
24 Jun 2007
Gene therapy with PD patients was safe and effective in a Phase I clinical trial.
24 Jun 2007
Mac Casale, Ph.D. reviews a poster presentation on a research study involving BDNF.
21 Jun 2007
Researchers report solid progress since the 2006 HDSA convention.
18 Jun 2007
Researchers report solid progress since last year.
29 May 2007
Oxidative stress causes ongoing CAG expansion.
19 May 2007
Researchers confirmed the obvious - that a caregiver's perception of progression is different than that of the HD patient.
19 May 2007
Researchers generated a mouse which progressively lost Dopamine 1 receptor cells and got Huntington's Disease like symptoms.
18 May 2007
A new studies identifies potential genetic modifiers of HD.
18 May 2007
Another way to turn off genes is discovered.
1 Apr 2007
The antibiotic clioquinol, a known copper chelator, helps the R6/2 mice.
1 Apr 2007
Researchers have discovered that excess copper plays a role in Huntington's Disease pathology.
29 Mar 2007
The University of Iowa is asking for young adults to participate in a research study about growing up as a teenager in an HD family.
29 Mar 2007
A study of curcumin (curry) in a toxin model of HD shows promise.
19 Mar 2007
A new review of the research literature shows that adenosine receptors have a complex role in Huntington
22 Feb 2007
Significant research is taking place in all the disciplines that lead from basic research to an approved treatment.
13 Feb 2007
New findings based on new technology show that the HD protein is being misdirected within the cell. Small molecules are being developed which might place a 'molecular zip code' on the problem.
9 Feb 2007
Having friends decreases the risk of developing Alzheimer's.
6 Feb 2007
Problems with NCAMs may explain cognitive and olfactory dysfunction in HD.
5 Feb 2007
Amarin Corp. and the HSG have completed a Phase III clinical trial of Miraxion which investigated whether the drug improves motor symptoms in HD.
4 Feb 2007
Members of the Huntington Study Group held their quarterly press conference with Huntington’s Disease family reporters Steve Ireland from the Huntington’s Disease Advocacy Center, Don Lamo
23 Jan 2007
Family members talk about coping with changes in gene positive family members before diagnosis.
16 Jan 2007
Avicena is planning a phase II toxicology trial for its creatine product followed soon by a phase III trial.
15 Jan 2007
Pronounced mood dysfunction in HD is associated with damage to the GAMA alpha receptors (the connection between neurons and target tissue)in the striosomes compartment of the brain's striatum. Since
26 Dec 2006
Depression and irritability precede clinical onset.
22 Dec 2006
The first clinical trial of stem cell therapy for a neurodegenerative disorder has begun.
21 Dec 2006
Minocycline is ineffective in the N171-82Q HD mouse.
21 Dec 2006
Minocycline may exert neuroprotective effects by blocking a protein that causes inflammation and cell death.
19 Dec 2006
Stem cells are still present in the middle aged brain; they just aren't dividing.
16 Dec 2006
CHDI is funding research on compounds related to a neurotrophic factor for testing in a mouse model of HD.
11 Dec 2006
We ask researchers to help us and often they, in turn, ask us to help them. Here is another great opportunity for us to help our researchers help us.
9 Dec 2006
A study with YAC128 mice suggests that overexpression of the normal huntingtin's protein is not enough to counteract all the negative effects of the HD protein.
9 Dec 2006
This article shows that not every child at risk for Huntington
8 Dec 2006
A company currently doing stem cell research in animal models of HD, has filed an application with the FDA for permission to begin clinical trials of stem cell treatments for stroke victims.
4 Dec 2006
A family advocate reports on this important meeting.
3 Dec 2006
Chorea decreased significantly in a small pilot study of memantine.
2 Dec 2006
Caregivers of JHD patients share their experiences with researchers.
29 Nov 2006
Four cases of JHD presented and proceded very differently from each other and from adult HD.
29 Nov 2006
CHDI is funding exciting new efforts to develop HDAC inhibitors.
25 Nov 2006
JHD varies by age of onset.
25 Nov 2006
Counseling for predictive HD tests is largely unavailable in India.
29 Oct 2006
Speech delay is an early symptom in JHD.
22 Oct 2006
Another review of animal studies shows the importance of exercise for neuroprotection.
21 Oct 2006
The Mediterranean diet may be a good choice for those at risk for HD.
19 Oct 2006
The results of a Phase I trial of gene therapy in Parkingon's Disease were announced by Ceregene last week and they also look promising.
17 Oct 2006
The results of a Phase I clinical trial with PD patients are encouraging.
15 Oct 2006
A revolutionary new statistical method could allow all study participants to take the therapeutic agents themselves — no one would have to take a placebo.
1 Oct 2006
The PREDICT-HD study is currently recruiting gene negative individuals.
30 Sep 2006
Many people with Huntington's Disease enjoy volunteering and making a difference in their communities.
28 Sep 2006
Medivation, Inc. announces that the FDA has approved a safety and tolerability trial for the use of Dimebon for HD. The trial will be conducted by the Huntington's Study Group under the direction of
18 Sep 2006
It has been awhile since a review of CAG counts in Huntington's Disease was published, so the new article by Dr. Michael Hayden and colleagues is very helpful. Here's a review of the latest informatio
10 Sep 2006
Phil Hardt reports on the living conditions and the need for help by an HD community in Juan de Acosta, Colombia.
9 Sep 2006
Ampakines may become a treatment for HD in the next few years.
2 Sep 2006
This Web site will be a wonderful resource for our UK readers who are looking for clinical trials in which to participate plus the information about the research will be of interest to everyone.
27 Aug 2006
If you are looking for assistance with applying for social security disability for someone disabled by Huntington's Disease then you will find it hard to more help than what Phil offers here.
26 Aug 2006
We were invited to attend this year’s meeting of the Hereditary Disease Foundation to learn about the progress being made and to share the broad findings with other HD family members. There were 350
21 Aug 2006
One in eight adults have dystonia rather than chorea as their predominant movement disorder.
21 Aug 2006
The Robert Woods Johnson Foundation has convened a number of workgroups to promote excellence in care for Huntington.
21 Aug 2006
Australian doctors outline a strategy for the General Practitioners to deal with the occasional rare disease that they encounter.
5 Aug 2006
RNAi continues to show great therapeutic potential after just a decade of experimental use.
1 Aug 2006
CHDI has contracted with Edison Pharmaceuticals to develop a variation of COQ10 that will be much more effective for those with HD.
29 Jul 2006
The polyglutamine expansion that causes HD may be an evolutionary 'experiment' to preserve brain function during periods of malnutrition.
22 Jul 2006
Mice engineered without CAG repeats are normal when born but develop cognitive deficits later on.
16 Jul 2006
Osessions and compulsions become more likely as the disease progresses but are not an inevitable part of the disease.
9 Jul 2006
The results of the first 17 months of the Predict-HD study have been published.
9 Jul 2006
Will is a participant in the PREDICT-HD study. His experiences in the study are entertaining as well as enlightening.
16 Jun 2006
This landmark study by long time HD researcher Michael Hayden and colleagues points us in a new direction for the development of a treatment.
4 Jun 2006
Higher doses of CoQ10 extend the lives of the HD mice even further.
29 May 2006
Participants needed for voice study. Qualifiers are those that are gene positive but non-symptomatic.
29 May 2006
The results of a Phase II clinical trial of a dopaminergic stabilizer for HD patients look promising and Carlsson Research is planning Phase III trials.
29 May 2006
There's a new reason to add blueberries to your diet - it restores the cell's ability to generate the heat shock protein 70 which normally declines with aging.
18 May 2006
Full text of a review of medications for HD symptoms is provided by permission.
16 May 2006
Volunteers needed to participate in a study to determine the value of MRI scans in evaluating pre-symptomatic progression.
13 May 2006
Another good bet for your diet.
11 May 2006
Research into using the brain's own 'hibernating' neural stem cells to repair brain damage advances in animal models.
28 Apr 2006
A review of research with trehalose shows that it has potential for both prevention and treatment of neurodegenerative diseases. ...
25 Apr 2006
Book review by Malcom Casale, Ph.D. ...
23 Apr 2006
Fascinating and promising research with mice suggests that gene silencing could help late stage HD patients. ...
22 Apr 2006
Social interaction can help prevent Alzheimer's ...
10 Apr 2006
Lower levels of BDNF in a mouse model were associated with earlier and more severe motor dysfunction. ...
5 Apr 2006
The right diet can help brain functioning. ...
5 Apr 2006
New research suggests that physical exercise encourages healthy brains to function at their optimum levels. Fitness prompts nerve cells to multiply, strengthens their connections, and protects them fr
2 Apr 2006
Will shares with us how he approaches living with a postitive test for the Huntington's Disease gene. ...
24 Mar 2006
Jim Tretheway, a leading advocate for HD patients offers some valuable insight into what can be done today to fight Huntington's Disease. ...
22 Mar 2006
In a new study, HD family members discuss how they learned about Huntington's Disease. ...
18 Mar 2006
Lighthouse contributing editor LaVonne Goodman reports on a landmark conference. ...
12 Mar 2006
The first day finishes...
11 Mar 2006
The first day continues...
10 Mar 2006
Event coverage: Eighth Annual Meeting of the American Society of Experimental Neurotherapeutics. ...
9 Mar 2006
We look forward to hearing much more about the channel hypothesis from pharmaceutical companies and academic scientists who will be searching for compounds to prevent channel formation in HD....
4 Mar 2006
Valproic acid treats myoclonus in HD patients. ...
25 Feb 2006
The tetrabenazine studies that the Lighthouse has been reporting on for the last year have been published. ...
15 Feb 2006
The protein ubiquilin is implicated in both Alzheimer's and Huntington's Disease. ...
30 Jan 2006
A well done new study of creatine shows that it is safe, tolerable, and reduces a biomarker of DNA oxidative injury. ...
28 Jan 2006
An FDA decision on tetrabenazine is expected in two months or so. ...
23 Jan 2006
Lighthouse contributing editor LaVonne Goodman reports on a meeting at CHDI. ...
13 Jan 2006
MAPK/ERK and SAPK/JNK pathways are affected by mutant huntingtin. Researchers were able to manipulate the pathways to prevent problems caused by mutant huntingtin in the cellular model they used. ...
3 Jan 2006
Surprising findings about huntingtin aggregation... ...
29 Dec 2005
Mutant huntingtin accumulates in glial nuclei in HD brains and decreases the expression of glutamate transporters. ...
19 Dec 2005
More research on the beneficial affects of SSRI antidepressants. ...
19 Dec 2005
A new gene therapy technique in Parkinson's Disease could hold promise for HD. ...
19 Dec 2005
Researchers are using mathematical modeling to gain new insights about Huntington's Disease. ...
13 Dec 2005
Neurotrophins are candidates for treatment in Huntington's Disease. ...
12 Dec 2005
FGF-2 promotes neurogenesis and increases survival time in the HD mouse. ...
11 Dec 2005
BDNF causes neurogenesis in the striatum in primates. ...
11 Dec 2005
We have achieved a milestone in HD research: the first study to demonstrate an additive effect in a combination trial with HD mice. ...
8 Dec 2005
Two members of the HDLighthouse editorial staff were guests at the 2005 Huntington Study Group meeting. ...
1 Dec 2005
...
6 Nov 2005
Prozac delays onset in the HD mice. ...
31 Oct 2005
Dr. Elena Cattaneo and colleagues have discovered another HD pathology. ...
18 Oct 2005
A better understanding of heat shock proteins may lead to HD treatments. ...
3 Oct 2005
Blueberries reverse some of the declines caused by aging. ...
27 Sep 2005
Dopamine appears to play a complex role in HD pathology. ...
23 Sep 2005
N-Acetyl Aspartate (NAA) is a promising biomarker for disease progression. ...
17 Sep 2005
There is a new interest in computer simulations of the HD protein. ...
14 Sep 2005
A study Of trehalose for AD supports its use In HD....
27 Aug 2005
Retreat for At-Riskers at The Pines Resort at Bass Lake, California Oct. 7-9. Register NOW! ...
24 Aug 2005
Cellular energy is inversely correlated with the number of CAG repeats. ...
22 Aug 2005
The High Q Foundation will fund preclinical studies of the use of AV-101, a neuroinhibitory compound. ...
16 Aug 2005
A new study finds biomarkers which could be used to shorten research time. ...
11 Aug 2005
Following the recent 2CARE editorial, several Lighthouse readers have requested more information regarding our stated support of clinical trials using combinations. We believe the primary goal of clin
11 Aug 2005
The Lighthouse has been following research with creatine for some years now. It's encouraging to learn that leading researchers feel that it may become the cornerstone in an HD cocktail. ...
26 Jul 2005
Highly increased amounts of ferritin, a molecule that carries iron, have been discovered in HD mice and tissue from symptomatic individuals. ...
17 Jul 2005
Researchers have discovered a key regulatory molecule whose overactivation by the abnormal protein produced in Huntington's disease (HD) causes the central pathologies of the disease. The abnormal HD
13 Jul 2005
Is a 5 year, 10 million dollar CoQ-10 trial in the best interest of HD+ patients? This article discusses aspects of the trial and concludes that there may be a better choice. This is something that w
9 Jul 2005
Cystamine's effects in mitigating HD appear to be indirect. ...
9 Jul 2005
Cystamine's therapeutic mechanism is not the inhibition of tissue transgluataminase. ...
9 Jul 2005
Cystamine is neuroprotective in the R6/2 mice. ...
5 Jul 2005
Celeastrol is neuroprotective in a toxin model of HD. ...
19 Jun 2005
This generation of HD families depends on the research community to act now...
11 Jun 2005
HD researchers discuss compounds that are are immediate candidates for human clinical trials in HD patients. ...
31 May 2005
It has been one year ago today when we lost our friend and fellow HD warrior Jerry Lampson who founded and served as Lighthouse Keeper for the HD Lighthouse for seven years. We miss you, Jerry. ...
30 May 2005
Korean scientists make major advances in stem cell research. ...
29 May 2005
Recent findings in food chemistry show that a toxic compound forms in highly unsaturated cooking oils. ...
28 May 2005
Celecoxib (a COX-2 inhibitor) shortens life expectancy in the HD-N171-82Q mouse. ...
18 May 2005
Tabrizi and colleagues have now published results for their much awaited two year follow-up study of creatine. ...
6 May 2005
The HD protein elicits toxic interactions from neighboring cells. ...
13 Apr 2005
A adenosine receptor agonist delayed the progressive deterioration of motor performance and prevented a reduction in brain weight in a mouse model of HD. ...
13 Apr 2005
Antioxidants reduced damage from stroke in rats. ...
11 Apr 2005
Haldol is associated with loss of brain volume in first episode psychotics. Patients treated with an atypical neuroleptic, olanzapine (Zyprexa), did not experience such loss. ...
4 Apr 2005
*Updated 4/9* Dr. Beverly Davidson brings us another step on the road to RNAi therapy. ...
28 Mar 2005
Combination drug therapy ameliorates the cognitive deficits of the R6/2 mice. ...
17 Mar 2005
Using a lentiviral vector, researchers have successfully used RNAi therapy with a mouse model of ALS. ...
13 Mar 2005
Additional evidence for the role of excitotoxicity in HD pathology is provided by this study. ...
13 Mar 2005
Dr. Tanaka and colleagues are again making the case for trehalose to be considered as a potential HD treatment. ...
13 Mar 2005
A large, open label study of tetrabenazine shows good results. ...
13 Mar 2005
Memantine, a drug approved for Alzheimer's treatment in the U.S., may treat Huntington's Disease. ...
4 Mar 2005
Tetrabenazine trial results were presented at the 7th Annual Meeting Society for Experimental7th Annual Meeting NeuroTherapeutics. ...
2 Mar 2005
A nonviral vector for RNAi therapy works in a cell model of HD. ...
24 Feb 2005
A protein that stimulates the cell's defense mechanisms is being researched as a treatment for neurodegenerative disorders.
16 Feb 2005
In developing these drug combinations, Marsh and Thompson chose compounds that individually have been shown in other fruit-fly tests and in mouse models to suppress neurodegeneration, but each targets
12 Feb 2005
Mitochondria impairment occurs early in the Huntington's Disease process. ...
29 Jan 2005
The Huntington's Study Group is off to a good start in 2005. ...
29 Jan 2005
A long term trial of creatine is warranted, according to a recent study of brain metabolite levels in HD patients treated with the supplement. ...
22 Jan 2005
A small open label study of rivastigmine suggests that it may have a slight, positive effect in ameliorating cognitive and motor symptoms ...
16 Jan 2005
An important new study supports celastrol, the active ingredient in a Chinese herb, as a promising potential treatment. ...
15 Jan 2005
Variations in the TP53 and hCAD genes influence the age of onset for HD. ...
15 Jan 2005
Huntington's disease disrupts the circadian clock. ...
15 Jan 2005
GDNF trials in PD patients may have been halted too soon. ...
14 Jan 2005
Stress and diet influence each other. ...
12 Jan 2005
Researchers have discovered four compounds which can inhibit huntingtin's aggregation in cell models and a fruitfly model of HD. ...
3 Jan 2005
Laura Jean, an HD positive Yoga instructor, uses Yoga to relieve symptoms. Laura inspired participants during a workshop she gave at the Guthrie Center in August, 2004. ...
2 Jan 2005
Early HDDW results look promising. ...
31 Dec 2004
A large, comprehensive study funded by the U.S. Dept. of Agriculture finds which foods are highest in antioxidant capacity. ...
7 Dec 2004
AD researchers, looking for a dietary approach to treatment, have become interested in research curcumin, the spice in curry. Curcumin is an antioxidant and a powerful inducer of the heat shock respo
7 Dec 2004
The latest discovery of spherical huntingtin protein aggregates, more microscopic than the previously known inclusions, points to activation of heat shock proteins as a major potential therapy. ...
5 Dec 2004
A drug as good as mithramycin in the mouse model should be brought to clinical trial. Why hasn't this gone farther than the thinking stage? ...
24 Nov 2004
Mithramycin, an antibiotic used in the treatment of certain cancers, extends survival, improves motor performance, and delays neurological in damage in the Ru6/2 HD mice. This are the best results fo
11 Nov 2004
A new analysis of data from past studies shows that high doses of Vitamin E are associated with higher rates of dying. ...
7 Nov 2004
Autophagy within the cell is relevant both to the disease process and the design of treatments for Huntington's. New work is adding to scientists' knowledge. ...
6 Nov 2004
Huntington's Disease causes the same kind of cell death in the hypothalamus that is found in narcolepsy. This explains the excessive sleeping of people with Huntington's Disease. ...
4 Nov 2004
Celastrol , derived from an herb used in traditional Chinese medicine for many years, shows promised as a treatment for HD. ...
30 Oct 2004
Neither aspirin nor Vioxx, drugs selected for their anti-inflammatory properties, help either of two models of HD mice, a new study reports. ...
25 Oct 2004
Phenylbutyrate, a histone deacetylase (HDAC) inhibitor, has been shown to be neuroprotective in a mouse model of HD. ...
17 Oct 2004
Here is another HD mouse study showing the potential of cystamine for the treatment of HD. ...
17 Oct 2004
An exciting new robotic microscope has has shown that the aggregates of mutant protein that are found in the brains of HD patients and the HD mice do not cause cell death. ...
17 Oct 2004
A new open label study of minocycline looks promising ...
6 Oct 2004
A two year open label study of memantine with HD patients found that disease progression was slower than expected. ...
2 Oct 2004
A case report of identical twins has shown that mosaicism can involve contractions of the CAG repeats. ...
2 Oct 2004
Dr. Eric Kmiec and colleagues at the University of Delaware and Massachusetts General Hospital have been able to inhibit HD protein aggregation in a cell model by using an oligonucleotide (a short, sy
26 Sep 2004
At the time of this update, there are 24 people who have completed enrollment in HDDW Individual Therapeutic Trials. Another 12 are close to completion of the enrollment process. Twelve participants
18 Sep 2004
New research has found that BDNF, which is known to be reduced in HD, acts on mRNA far away from the neucleus in the part of the neuron called the synapse. The synapse is responsible for communication
18 Sep 2004
Impaired 5-HT and BDNF signaling is central to depression and anxiety disorders, but could also play important roles in the pathogenesis of several age-related disorders, including insulin resistance
10 Sep 2004
Imagine a professional HD clinical trial company: One that would do clinical trials for HD full-time, and one that could form a “joint venture” with “for profit” drug companies. Many pharmaceutical c
9 Sep 2004
We have developed a medium-throughput cell-based assay to screen drugs for Huntington's disease (HD). The assay measures the ability of drugs to protect cultured neuronal (PC12) cells from death ca
5 Sep 2004
There have long been hints from epidemiological studies that dietary supplements of omega-3 polyunsaturated fatty acids might protect against Alzheimer's disease (AD). Now studies by Greg Cole and
24 Aug 2004
A re-analysis of the Lax 101 data (now called Miraxion) shows improvement in a subgroup of research participants with fewer than 45 CAG repeats who were given the drug. In contrast, those in the cont
23 Aug 2004
Every two years the Hereditary Disease Foundation (HDF) has a conference that showcases research and researchers supported by HDF. Many of these same efforts are also funded by HDSA and High Q. Ear
22 Aug 2004
Two Phase II trials with minocycline have ended and both found minocycline to be safe and tolerated by Huntington's Disease patients. ...
10 Aug 2004
The study referred to in the press release is a dramatically different view of what goes wrong in the HD cell than is found in traditional HD research. The traditional view is that the HD protein, hun
5 Aug 2004
Recently we noted the lack of clinical trials for medications to treat HD symptoms. Neuroleptics or antipsychotic drugs are frequently prescribed for the psychiatric symptoms of patients with HD and
30 Jul 2004
The antibiotic rapamycin is being researched as a potential treatment for Huntington’s Disease. Rapamycin has had good results in a cell, fruit fly and mouse model. Since the results from the cell m
25 Jul 2004
While we are all grateful for the research into potential treatments for Huntington’s Disease, in the meantime research into treatments of the symptoms has lagged behind. This is why it’s so importan
23 Jul 2004
The major conclusion of this study will come as no surprise to longtime readers of the Lighthouse. It is news, however, that the HD protein causes abnormalities but not dysfunctions in cells in the sk
21 Jul 2004
Scientists have found a way of successfully treating flies that were given human degenerative brain diseases. ...
20 Jul 2004
The HD Drug Works program is off to a good start. Over the past month, the first wave of HDDW participants fired up their computers, logged on with unique identifiers, and tapped. And so began baselin