Symptoms of HD

Pronounced mood dysfunction in HD is associated with damage to the GAMA alpha receptors (the connection between neurons and target tissue)in the striosomes compartment of the brain's striatum. Since

Depression and irritability precede clinical onset.

One in eight adults have dystonia rather than chorea as their predominant movement disorder.

Osessions and compulsions become more likely as the disease progresses but are not an inevitable part of the disease.

Huntington's Disease causes the same kind of cell death in the hypothalamus that is found in narcolepsy. This explains the excessive sleeping of people with Huntington's Disease. ...