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Editor's Comment: The authors review the evidence that diminished plasticity is a major pathology in both Huntington's and Alzheimer's.
Neurodegenerative diseases such as Huntington's disease and Alzheimer's disease, although very different in etiology, share common degenerative processes. These include neuronal dysfunction, decreased neural connectivity, and disruption of cellular plasticity. Understanding the molecular mechanisms underlying the neural plasticity deficits in these devastating conditions may lead the way toward new therapeutic targets, both disease-specific and more generalized, which can ameliorate degenerative cognitive deficits. Furthermore, investigations of 'pathological plasticity' in these diseases lend insight into normal brain function. This review will present evidence for altered plasticity in Huntington's and Alzheimer's diseases, relate these findings to symptomatology, and review possible causes and commonalities.
Source: Journal of Neurochemistry 2007 Jan 8; [Epub ahead of print]
Printed: 10 Sep 2010
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Article posted to www.HDlighthouse.org on: 01-18-2007